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University of Iowa
Division of Medical Genetics
Testing Protocols
Breast/Ovarian Cancer Risk Counseling Protocol Guidelines
- Initial contact of individuals referred for breast/ovarian cancer risk counseling can be
by telephone or in person. The initial visit consists of sections I, II, and the detailed family
history in part III of the Breast/ovarian cancer counseling protocol. Individuals may also be
asked to contact affected family members to obtain release of information for relevant medical
records.
- Assign risk based on Claus models, GAIL model, pedigree analysis and medical information
obtained on affected individuals.
- The next visit will consist of sections IV, V, and VI. This will be a clinic appointment.
Individuals with moderate to low breast/ovarian cancer risk will be referred back to their local
health care provider to discuss their surveillance options. Individuals with high risk will be
offered information about DNA testing.
- It is optimal for individuals who are considering DNA testing to delay testing for 2-4
weeks so they can weigh risks, limitations, and benefits of testing. If the individual is
presymptomatic an affected relative will need to be tested first. Some individuals who opt for
testing may need a support person to accompany them through the testing procedure.
- Results of testing will be shared with the individual in person at a clinic appointment.
- If DNA testing confirms a breast/ovarian cancer susceptibility gene, testing can be
offered to at risk family members who are 18 years or older. Woman found to have a mutation in
the susceptibility gene will be referred to their local health care provider or to the UIHC
cancer center for screening/treatment options. Woman who are found to be at low risk for a
susceptibility gene will be given the general population cancer risk and referred back to their
local health care provider for routine screening. If DNA studies do not implicate one of the
cancer susceptibility genes, personal risk will be calculated based on GAIL, Claus and/or
pedigree. They will be referred to their local health care provider or the UIHC cancer center
for screening/treatment options.
Copyright 1997, University of Iowa, Division of Medical Genetics
Copyright © 2010, ISONG |
